What is MPV in blood test and What Can Abnormal Levels Indicate?

What is MPV in blood test and What Can Abnormal Levels Indicate?

MPV, which stands for Mean Platelet Volume, is a valuable parameter measured in blood tests that provides insights into platelet characteristics. Platelets, also known as thrombocytes, play a crucial role in the clotting process, preventing excessive bleeding and promoting wound healing. The MPV refers to the average size of these platelets in the bloodstream and is typically reported in femtoliters (fL). By assessing the MPV, healthcare professionals can gain important information about platelet production, activation, and overall platelet function. This measurement serves as an essential component in the comprehensive analysis of blood samples and aids in the diagnosis and monitoring of various medical conditions. In the following paragraphs, we will delve deeper into what is mpv in blood test and its clinical implications.

What is an MPV Blood Test?

The acronym MPV stands for mean platelet volume, referring to the average size of platelets, which are tiny blood cells responsible for clot formation and wound healing. Platelets are produced in the bone marrow. An MPV blood test measures the size of platelets, aiding in the diagnosis of bleeding disorders and bone marrow-related diseases.

What is it used for?

The MPV blood test serves as a diagnostic and monitoring tool for various blood-related conditions. Additionally, it can provide insights into the severity of other health conditions. Typically, the MPV test is accompanied by a platelet count, which determines the total number of platelets present in the blood.

What is the normal range for MPV in a blood test?

The normal range for MPV (mean platelet volume) in a blood test can vary slightly depending on the laboratory and the specific measuring techniques used. Generally, the reference range for MPV is around 7.4 to 10.4 femtoliters (fL).

What are the factors that can affect MPV levels?

Several factors can affect MPV (mean platelet volume) levels in a blood test. These factors include:

  • Age 

MPV levels tend to be higher in newborns and infants, gradually decreasing as individuals age.

  • Platelet production 

Conditions that affect platelet production, such as bone marrow disorders or certain medications, can influence MPV levels. For example, in conditions like immune thrombocytopenic purpura (ITP) or chemotherapy, where platelet destruction or suppression occurs, MPV levels may increase.

  • Inflammatory conditions 

Inflammatory responses in the body can lead to changes in MPV levels. Conditions like infections, autoimmune disorders, and chronic inflammatory diseases may cause an elevation in MPV.

  • Medications 

Some medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can impact MPV levels. It’s important to inform your healthcare provider about any medications you are taking before undergoing an MPV blood test.

  • Genetic factors 

Certain genetic disorders, such as Bernard-Soulier syndrome or Gray platelet syndrome, can cause variations in platelet size and subsequently affect MPV levels.

  • Platelet activation 

Increased platelet activation, as seen in conditions like cardiovascular diseases or acute coronary syndromes, can lead to higher MPV levels.

  • Blood loss or transfusion 

Significant blood loss or transfusion of blood products can temporarily affect MPV levels.

What does a high and low MPV indicate in a blood test?

MPV Level Potential Interpretation
High MPV                 Increased platelet production in response to certain conditions or situations, such as rebound thrombocytosis, recovery from iron deficiency anaemia, or after resolving an infection.
Platelet destruction or consumption due to conditions like immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), or disseminated intravascular coagulation (DIC).
Inflammatory or autoimmune disorders that lead to increased platelet activation and release of larger platelets from the bone marrow.
Association with cardiovascular diseases and increased risk of events like myocardial infarction or stroke.
Medications, such as NSAIDs, that can cause a temporary increase in MPV levels.
Low MPV Decreased platelet production in the bone marrow, which can be associated with conditions like aplastic anaemia, chemotherapy or radiation therapy, or certain genetic disorders affecting platelet production.
Increased platelet destruction or consumption, as seen in conditions like immune-mediated thrombocytopenia or hypersplenism.
Inherited disorders affecting platelet production or function, such as Bernard-Soulier syndrome or Gray platelet syndrome.
Medications or treatments that can temporarily suppress platelet production or increase platelet clearance.

It’s important to note that these are general associations and further evaluation by a healthcare professional is necessary to determine the underlying cause and appropriate treatment plan for abnormal MPV levels.


Q1: What is the significance of MPV in a blood test?

Ans: MPV provides insights into platelet characteristics and helps diagnose various conditions.

Q2: Can high MPV levels indicate cardiovascular risk?

Ans: Studies suggest a link between elevated MPV and increased risk of cardiovascular events.

Q3: What conditions can cause a low MPV?

Ans: Low MPV may be associated with aplastic anemia, chemotherapy, or platelet destruction disorders.

Q4: What is the normal range for MPV in a blood test?

Ans: The normal range for MPV is typically around 7.4 to 10.4 femtoliters (fL).

Q5: Can MPV be used as a diagnostic marker for bleeding disorders?

Ans: MPV can help in diagnosing bleeding disorders and diseases of the bone marrow.

Share this post

Post Comment